Holders Manchester United were handed another potentially easy tie when they were drawn away to Championship side Southend United in the League Cup fourth round on Wednesday. Manager Alex Ferguson will, however, be wary of taking the opposition too lightly after his team only managed to subdue League One Crewe Alexandra 2-1 after extra time in their third-round clash on Wednesday night.

"I'm sure it will be a good game for us but I hope the boys will learn from tonight," Ferguson told Sky Sports after fielding several second string players at Crewe.

After overcoming Blackburn Rovers 2-0 away Chelsea were given another tough draw – at home against Aston Villa, the only unbeaten team in the Premier League. Arsenal play at Everton and Newcastle United visit Watford in two more all-Premier League ties.

League One Chesterfield, who upset FA Cup runners-up West Ham United 2-1 on Tuesday, their second top-flight scalp in a row after beating Manchester City, are at home to the Premier League's bottom side Charlton Athletic.

"We're on a hat-trick," Chesterfield manager Roy McFarland enthused.

Port Vale, also League One, are away to Tottenham Hotspur who romped to a 5-0 win over fourth division MK Dons on Wednesday.

Spurs will be wary, however, of repeating their shock 2-1 defeat at Port Vale, then in the old third division, in an FA Cup fourth round tie in January 1988.

There will be at least one side from the lower leagues in the last 16 after the draw threw up a clash of League Two sides with Notts County hosting Wycombe Wanderers.

Liverpool, seven-times winners, visit second division Birmingham City whom they beat on penalties in the 2001 final.

Notts County  v Wycombe Wanderers

Tottenham Hotspur v Port Vale

Birmingham City v Liverpool

Chelsea v Aston Villa

Watford v Newcastle United

Chesterfield v Charlton Athletic

Southend United v Manchester United

Everton v Arsenal

Ties to be played week commencing November 6.